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Vaddi Mounika ¹, S. Sarumathy ¹, J. Anisha Ebens ¹, T. S. Shanmugarajan ¹

Affiliations
1 Department of Pharmacy Practice, School of Pharmaceutical Sciences, Vels University (VISTAS), Pallavaram, Chennai-600117, Tamilnadu, IN

Abstract

Aim and objective: This study is to determine the incidence of anaemia in type II diabetes mellitus patients. The study was carried out to determine the incidence of anaemia in type II diabetes mellitus patients, to identify the risk factors leading to anaemia associated with type II DM, to assess the Hb, Fasting Blood Glucose (FBG) and Glycosylated Haemoglobin (HbA1C) levels in diabetes mellitus patients. Methods: This prospective study was carried out in the general medicine and surgery department of a tertiary care hospital for a period of 6 months. The case reports of 112 patients with type 2 diabetes mellitus were collected. All statistical analysis was carried out using Graph pad Prism 6.0. Results: Anaemia with higher Hb level is observed in patients with type 2 diabetes mellitus. However statistical significant difference was only in Hb levels, Hba1c, FBG, Post-Prandial blood sugar (PPBS) was observed in anaemia with type 2 diabetes mellitus patients (P<0.001). Conclusion: A high incidence of anaemia was observed in diabetics without renal insufficiency. Our data also suggested that poor glycemic control and old age are associated with the incidence of anaemia in diabetic patients with normal renal function. Correction of anaemia may have a significant role in prevention of other diabetic complications, thus we recommend that treatment criteria for diabetes should include routine haematological tests and take into consideration the inevitable consequences of aging, and poor glycemic control, in order to make optimal therapeutic decisions for the treatment of diabetes mellitus in adults.

Keywords

Anaemia, Type 2 Diabetes Mellitus, Risk Factors, Comorbid Conditions.

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S. Kalaivanan ¹, S. Sarumathy ¹, J. Anisha Ebens ¹, K. Naresh Kumar ¹, A. Roobena Parveen ¹, M. Nasreen Ashraf ¹

Affiliations
1 Department of Pharmacy Practice, School of Pharmaceutical Sciences, Vels University (VISTAS), Pallavaram, Chennai-600117, Tamilnadu, IN

Abstract

Aim and Objective: The aim of study is to assess and compare the lipid profiles among diabetic and coronary artery disease (CAD) patients receiving statin therapy. Methods: This retrospective observational study was carried out in a cardiac specialty hospital for a period of 6 months from January - June 2015. The inclusion criteria included adult patients greater than 18 years of age with the diagnosis of coronary artery disease or diabetes mellitus receiving statin therapy. CAD patients with any other co morbidity were excluded in the study. Lipid profile such as low-density lipoproteins (LDL), high-density lipoproteins (HDL), very-low-density lipoprotein (VLDL), total cholesterol (TC), triglycerides (TGL) were assessed. Results: The overall prevalence of dyslipidemia in our CAD patients was greater. More number of male patients was affected with CAD and diabetes when compared to female patients. No significant changes were observed in HDL levels. The study concludes that the incidence and the lipid profile for both the study groups were found to be high. The lipid parameters were assessed and compared for both the study groups which showed statistically no significance difference. Aggressive therapy of diabetic dyslipidemia will probably reduce the risk of coronary heart diseases (CHD) in patients with diabetes. Lowering triglycerides and increasing HDL cholesterol with a fibrate is associated with a reduction in cardiovascular events in patients with clinical CHD, low HDL, and near-normal levels of LDL.

Keywords

Coronary Artery Disease, Diabetes Mellitus, Cholesterol.

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Mohamed Zerein Fathima ¹, T. S. Shanmugarajan ¹, I. Somasundharam ¹, J. Anisha Ebens ¹, T. T. Neethu ¹

Affiliations
1 Department of Pharmaceutics, School of Pharmaceutical Sciences, Vels University (VISTAS), Pallavaram-600117, Tamilnandu, IN

Abstract

Trichosanthes cucumerina linn is used as a traditional medicine for various diseases. In the present study was conducted to evaluate theanalgesic activity for Petroleum ether and Methanol extract of Trichosanthes cucumerinalinn and the activity was compared with diclofenac sodium as a standardand assessed using acetic acid induced abdominal writhing in mice.The methanolic extract exhibited significant value (P<0.001)analgesic activity as evidenced by increased the percentage of reduction in reaction time. The results thus support the Trichosanthes cucumerina linn used as ananalgesic agent. The plant showed no sign of toxicityup to the dose of 100 mg/kg in mice.

Keywords

Trichosanthes cucumerina linn, Analgesic Activity, Phytochemical Screening, Structural Elucidation, IR.

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